Spa DNA

Genome Research, vol. 36, no. 1 December, 2025

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Automated chromatin profiling with spa-ChIP-seq uncovers the impacts of condition variations. Yuwei Cao et al.

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Cover expansion: "The illustration depicts DNA molecules enjoying a “spa day,” symbolizing the single-pot automated ChIP-seq (spa-ChIP-seq) workflow presented in this issue. The DNA is shown crosslinked with proteins and immersed in a tub surrounded by floating antibodies, with some proteins bound by antibodies to represent immunoprecipitation of the target proteins. A 96-well plate and pipette tip overhead emphasize the automated and streamlined nature of the method. For simplicity, we show only one tip, while the process is designed for multiples of 8–96. Together, the artwork highlights how spa-ChIP-seq provides an easy, robust, and accessible approach to high-throughput chromatin profiling."

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2025​​​​​